Course Info
Note: This educational activity contains discussion of estrogen agonist/antagonist agents, which are commonly referred to as selective estrogen-receptor modulators (SERMs).
Target Audience
This activity is designed for gynecologists, internists, and endocrinologists with an interest in menopause and the use of SERMs.
Learning Objectives
After participating in this activity, gynecologists, internists, and endocrinologists should be better able to:
- Characterize the function and distribution of ERs and explain how they are clinically relevant
- Describe the actions and clinical significance of estrogen and SERMs in various tissues
Faculty
Donald P. McDonnell, PhD
Glaxo-Wellcome Professor of Molecular Cancer Biology
Department of Pharmacology & Cancer Biology
Duke University Medical Center
Durham, NC
Dr. McDonnell serves as the Director of the departmental graduate studies program and as the Associate Director for Basic Research for the Duke Comprehensive Cancer Center.
He came to Duke in 1994 from Ligand Pharmaceuticals, Inc., where he was the director and head of molecular biology. His work has focused in recent years on the genetic and pharmacological dissection of the steroid hormone receptor signal transduction pathways. The insights from this work have led to the discovery and development of novel estrogen and progesterone modulators that are being evaluated clinically as treatments for cancer and osteoporosis.
Dr. McDonnell has received numerous investigator awards, including the 2003 Ernst Oppenheimer and 1998 Weitzman Awards from The Endocrine Society, the American Society for Pharmacology and Experimental Therapeutics (ASPET) 1999 John J. Abel Award, the 2005 Pharmacia-ASPET Award for Experimental Therapeutics, and the 2000 NAMS/Eli Lilly and Company SERM Research Award. He was also recently elected to join the Council (primary governing body) of The Endocrine Society. Dr. McDonnell has published more than 200 articles on the molecular pharmacology of nuclear hormone receptors. Currently, he sits on the editorial board of Trends in Endocrinology and Metabolism. He holds an undergraduate degree from the University College of Galway, Ireland, and a PhD in Cell Biology from Baylor College of Medicine, Houston, Texas.
Education Council
The role of the education council is to provide overall direction and leadership for EMPREss (Enhancing Menopause management through understanding the Physiology of Receptors of Estrogen) educational initiative. For this confidence based learning activity the education council
- Validated and identified learner needs
- Planned and reviewed content
- Provided ongoing, formative evaluation
Arthur H. Bill Professor Emeritus of Reproductive Biology
Case Western Reserve University School of Medicine
Chairman, Advisory Board
Rapid Medical Research
Consultant, Obstetrics, Gynecology and Women’s Health Institute
Cleveland Clinic
Executive Director
The North American Menopause Society
Cleveland, OH
Paul D. Miller, MD
Distinguished Clinical Professor of Medicine
University of Colorado Health Sciences Center
Medical Director
Colorado Center for Bone Research
Lakewood, CO
JoAnn V. Pinkerton, MD, NCMP
Professor of Obstetrics and Gynecology
Vice Chair for Academic Affairs
Director, Midlife Health
University of Virginia Health Sciences Center
Charlottesville, VA
Cynthia A. Stuenkel, MD, NCMP
Clinical Professor of Medicine
University of California, San Diego
La Jolla, CA
Victor G. Vogel, MD, MHS, FACP
National Vice President, Research
American Cancer Society
Atlanta, GA
Method of Participation
Continuing Medical Education credit will be awarded to physicians who successfully complete this on-line educational activity. Participation should take approximately 1 hour. To complete this activity and receive credit, the participant should:
- Review the learning objectives
- Complete the on-line Confidence-Based Learning module
- Complete the post-course evaluation form
For questions regarding CME credit, please call Penn State Continuing Education at (717) 531-6483 or e-mail ContinuingEd@hmc.psu.edu. Please reference activity code G3993-09-T.
Accreditation Statement
This activity has been planned and implemented in accordance with the Essential Areas and Policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint sponsorship of Penn State College of Medicine, The North American Menopause Society, and Indicia Medical Education, LLC. Penn State College of Medicine is accredited by the ACCME to provide continuing medical education for physicians.
Credit Designation
Penn State College of Medicine designates this educational activity for a maximum of 1.0 AMA PRA Category 1 Credits™.
Original release date: August 14, 2009
Review/approval date: August 14, 2010
Expiration date: No credit will be given after August 14, 2010
Disclosure of Faculty and Planner Financial Affiliations
The program sponsors are committed to offering CME programs that promote improvements or quality in health care and are developed free of the control of commercial interests. Reasonable efforts have been taken to ensure that our programs are balanced, independent, objective, scientific, and in compliance with regulatory requirements. Faculty and course directors have disclosed all relevant financial relationships with commercial companies, and Penn State has a process in place to resolve any conflict of interest. Disclosure of a relationship is not intended to suggest or condone bias, but is made to provide participants with information that might be of potential importance to their evaluation of this educational activity.
The faculty reported the following financial relationships or relationships to products or devices they or their spouse/life partner have with commercial interests related to the content of this activity:
Donald P. McDonnell, PhD
Dr. McDonnell has disclosed the following relationships: He owns stock in, and holds patents/receives royalties from IOS Pharmaceuticals; he is a consultant/advisor for Schering Plough and Wyeth; and he receives grant research support from GlaxoSmithKline, Schering Plough, and Wyeth.
The education council reported the following financial relationships or relationships to products or devices they or their spouse/life partner have with commercial interests related to the content of this activity:
Wulf H. Utian, MD, PhD, DSc(Med)—Chair
Dr. Utian has disclosed the following relationships: He is a consultant/on the advisory board for Barr/Duramed, Bionovo, Depomed, Eli Lilly, GlaxoSmithKline, KV Pharmaceuticals, Merck Gynecology, Novartis, Reuters, Orcas Therapeutics, QuatRx, and Wyeth.
Paul D. Miller, MD
Dr. Miller has disclosed the following relationships: He is on the speaker’s bureau and advisory board and serves as a consultant for Amgen, Eli Lilly, GlaxoSmithKline, Procter & Gamble, Merck, Novartis, NPS, Roche, and Sanofi Aventis; and he receives research grant support from Amgen, Eli Lilly, Merck, Novartis, Procter & Gamble, Roche, and Sanofi Aventis.
JoAnn V. Pinkerton, MD, NCMP
Dr. Pinkerton has disclosed the following relationships: She is a consultant for Boehringer Ingelheim, Eli Lilly, Duramed, Novo Nordisk, and Wyeth; she is on the advisory board for the National Women's Health Resource Center and she receives research grant support from Solvay and Wyeth.
Cynthia A. Stuenkel, MD, NCMP
Dr. Stuenkel has disclosed the following relationships: She is a consultant for Eli Lilly, Upsher-Smith, and Wyeth. Dr. Stuenkel's spouse has disclosed the following relationships: He is a consultant for Boston Scientific, Gambro Renal Products, and Thoratec; he is on the speaker's bureau for GlaxoSmithKline and Thoratec; and he receives research grant support from Boston Scientific.
Victor G. Vogel, MD, MHS, FACP
Dr. Vogel has disclosed the following relationships: He is on the speaker's bureau for Eli Lilly, Genomic Health, and Novartis; he is a consultant/advisor for Eli Lilly and Genomic Health; and he receives research grant support from AstraZeneca, Eli Lilly, and Genomic Health.
Staff of Penn State College of Medicine, Indicia Medical Education, LLC, and The North American Menopause Society have no personal financial relationships with any commercial interests relevant to this activity.
The CBL questions were written by Shanna McClennen, PhD, based on information contributed by the faculty. Faculty reviewed, edited, and approved the final project. Dr. McClennen discloses that she has no personal financial relationships with any commercial interests relevant to this activity.
Disclosure of Discussion of non-FDA-approved Uses for Pharmaceutical Products and/or Medical Devices
Update Disclosure of Discussion of Unlabeled Use to read—Penn State College of Medicine, Indicia Medical Education, LLC, The North American Menopause Society, and Wyeth do not recommend the use of any agent outside of the labeled indications. The following FDA-approved drugs or drug classes are mentioned in this educational activity: bisphosphonates (alendronate, risedronate), conjugated estrogens (CEs), estrogen, and estrogen agonists/antagonists (selective estrogen-receptor modulators [SERMs], including arzoxifene, bazedoxifene, clomifene, raloxifene, and tamoxifen). This activity also contains discussion of investigational uses of agents that are not indicated by the FDA. The following investigational therapies are also discussed: tissue-selective estrogen complexes (TSECs).
Software Requirements
Disclaimer
The opinions expressed in this educational activity are those of the faculty and do not necessarily represent the views of Penn State College of Medicine, The North American Menopause Society, Indicia Medical Education, LLC, or Wyeth. Clinicians have an implied responsibility to use the newly acquired information to enhance patient outcomes and their own professional development. The information presented in this educational activity is not meant to serve as a guideline for patient management. Any procedures, medications, or other courses of diagnosis or treatment discussed or suggested in this educational activity should not be used by clinicians without careful evaluation of their patients’ conditions. Please refer to the official prescribing information and other authoritative sources for each product for discussion of approved indications, contraindications, and warnings, as well as recommendations of other authorities.
Penn State Privacy Policy
Penn State is committed to on-line privacy and confidentiality. This website is managed by Knowledge Factor, and their printed privacy policy applies to this site. CME credit is provided by Penn State College of Medicine. If you register for CME credit for this educational activity, Knowledge Factor will forward relevant personally identifiable information to Penn State College of Medicine so that we can maintain records concerning credits we issue to you. We may share aggregated data concerning registrations, post-tests, and evaluations on request of our joint sponsors and/or the commercial supporter. We will not share any personally identifiable information. Penn State College of Medicine may use the information you provide on this site to contact you about your CME credit or other relevant educational activities provided through Penn State College of Medicine. For more information, contact ContinuingEd@hmc.psu.edu.
© 2009 Indicia Medical Education, LLC
Jointly sponsored by Penn State College of Medicine, The North American Menopause Society, and Indicia Medical Education, LLC.
Supported through an educational grant from 